This can be an easy sign to notice, especially if you live a healthy and active life. If you exercise on a daily basis and have a healthy diet, weight gain should be a red flag for you. If you notice that you’re gaining weight, and it’s not from overeating or a hormonal imbalance, go see your doctor. When the liver is unable to deal with all the toxins coming through, it has to store the unfiltered toxins in fat cells. The only way to start losing weight again is if you help clean out your liver.